Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 2;119(10):1233–1243. doi: 10.1038/s41416-018-0286-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Multiplexed MRM-MS analysis of a panel of DDR related proteins, identifies pRAD50(Ser635) as an ATM-modulated biomarker with high dynamic range. Human PBMCs were either untreated or stimulated ex vivo with 5 Gy of ionizing radiation (IR) in the presence/ absence of AZD0156. a Comparison of peptide levels in baseline untreated PBMCs to IR treated PBMCs. b Comparison of peptide levels in IR treated PBMCs compared to IR and AZD0156 treated PBMCs. c Average concentrations of the total peptide and phosphopeptide analytes in fmol/mg for ATM (S2996 and S367) and RAD50 (S635) given for each treatment group. Peptide levels that were below the limit of quantification (LoQ) are indicated on the graph. See Supplementary Table 2 for LoQ values for each peptide