Fig. 5.

Tumour regrowth occurred after 2 weeks of PLX4720 mono- or combination therapy and coincided with a. A dramatic decrease in CD8⁺ cytotoxic T cells, granzyme B staining, and no change in FoxP3⁺ T cells, compared to 1 week of treatment. Three weeks of combination treatment was associated with further decreases in CD8⁺ cytotoxic T cells, granzyme B staining, and a dramatic increase in FoxP3⁺ T cells. N = 4 mice per group, repeated twice