Table 1.
The main developmental history of TRAF6.
| Time | Incident | Refs. |
|---|---|---|
| 1996 | The discovery of TRAF6, and it is the only one member of TRAF family that takes part in the signal transduction of TNFR and IL-1R/ TLR superfamily | (Ishida et al., 1996) (Cao et al., 1996) |
| 2000 | TRAF6 is found relevant to AD | (Akama and Van Eldik, 2000) |
| 2003 | TRAF6 is required for optimal DC maturation and activation | (Kobayashi et al., 2003) |
| 2004 | TRAF6 plays an essential role in NGF-dependent signaling pathway in Schwann cells | (Yeiser et al., 2004) |
| 2010 | the expression level of TRAF6 has been detected in nigral dopaminergic neurons | (Zucchelli et al., 2010) |
| 2011 | TRAF6 was first described in Traumatic brain injury | (Chen et al., 2011) |
| 2012 | The expression of TRAF6 increases after ischemic stroke | (Liu et al., 2012) |
| 2012 | TRAF6 is associated with Ischemia-reperfusion injury,and peaked at 1h after ischemic | (Yuan et al., 2013) |
| 2013 | The characteristic of TRAF6,E3 ubiquitin ligase,is highly related to ischemic stroke | (Wu et al., 2013) |
| 2013 | TRAF6 promotes Akt activation in the process of TBI | (Farook et al., 2013) |
| 2013 | TRAF6 mediated autophagy in AD | (Salminen et al., 2013) |
| 2014 | TRAF6 mediated inflammatory response in AD | (Olajide et al., 2014) |
| 2014 | TRAF6 may aggravate neuropathic pain through JNK/CCL2 pathway | (Lu et al., 2014) |
| 2015 | MicroRNA-146a-5p releaves neuropathic pain by inhibiting TRAF6 | (Lu et al., 2015) |