Table 3.
SGHV-encoded orthologs of cellular genes: The protein families shown in this table were restricted to those that showed significant domain structural conservations. The proteins listed here have been described during the reporting of the genome sequences of the SGHVs [4–6]
| Protein Name | GpSGHV ORF (ORF No.) | Location in virus particle | MdSGHV (ORF No.) | Homology or description | |
|---|---|---|---|---|---|
| GpSGHV-Eth | GpSGHV-Uga | ||||
| Lecithine-cholesterol acyltransferase (T, P) | 5 | 5 | ICSVP £ | 46 | Pseudomonas sp. |
| D-3-phosphoglycerate dehydrogenase (T, P) | 6 | 7 | Tegument | – | Clostridium ultunense |
| MAL7P1.132 (T, P) | 8 | 9 | ICSVP | – | Plasmodium falciparum Str. 3D7 |
| UDP-glucose-6 dehydrogenase (T) | 13 | 16 | Unknown | – | Pseudobutyrivibrio ruminis |
| NADH ubiquinone oxidoreductase (T) | 30 | 29 | Virion protein | – | Styphylococcal AgrD protein |
| Maltodextrin glycosyltransferase (T, P) | 39 | 38 | Tegument | – | RGD-domain containing protein |
| Glutathione S-transferase (T, P) | 48 | 46 | Tegument | 84 | Pre-mRNA splicing factor |
| Cellular protein CBG22662 (T, P) | 49 | 47 | Tegument | – | Coenorhabditis briggsae |
| Rhoptry protein kinase (T) | 58 | 57 | – | – | Plasmodium yolei Str. 17XNL |
| Signaling mucin HKR1 | 64 | – | – | – | Xenopus (Silurana) tropicalis |
| RpoD protein (T) | 66 | 59 | – | – | Plasmodium falciparum |
| ECF transporter (T, P) | 75 | 68 | Envelop | – | – |
| Cellular protein PY00593 (T, P) | 124 | 113 | Nucleocapsid | NaN | Plasmodium yolei Str. 17XNL |
| Tail length tape-measure (T, P) | 149 | 134 | ICSVP | – | Oenococcus phage phi9805 |
Expression confirmed by transcriptomics (T) and proteomics only (P). Unmarked genes have no detectable transcripts or peptides; £ These proteins do not have specific localization and were designated as ‘infected cell-specific viral proteins (ICSVP)’ [6]