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. 2018 Nov 22;11:131. doi: 10.1186/s13045-018-0673-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Different strategies of CRISPR-Cas system for targeting lncRNA. a Removing the entire locus of an lncRNA gene via sgRNA-mediated cleavage by Cas9. b Solely deleting the promoter region of an lncRNA gene by CRISPR-Cas9. c Silencing an lncRNA gene by knocking-in transcription termination signal. d Suppressing or enhancing lncRNA expression by CRISPRi/a. e Cleaving lncRNA transcripts by CRISPR-Cas13 system