Table 2.
Demographic, infection, and admission characteristics of patients with severe sepsis (n = 1184)
| Characteristics | |
|---|---|
| Age at admission, years | 73 (64–81) |
| Male | 719/1184 (60.7) |
| BMI, kg/m2 | 22 (19–25) |
| Admission source | |
| ED | 676 (57.2) |
| non-ED (hospital/department transfers) | 457 (38.7) |
| ICU | 49 (4.1) |
| Coexisting conditions | |
| Myocardial infarction | 58 (4.9) |
| Congestive heart failure | 128 (10.8) |
| Peripheral vascular disease | 29 (2.4) |
| Cerebrovascular disease | 140 (11.8) |
| Dementia | 97 (8.2) |
| COPD | 82 (6.9) |
| Connective tissue disease | 83 (7.0) |
| Peptic ulcer disease | 32 (2.7) |
| Diabetes mellitus without organ damage | 197 (16.6) |
| Diabetes mellitus with organ damage | 75 (6.3) |
| Chronic kidney disease | 85 (7.2) |
| Hemiplegia | 44 (3.7) |
| Malignancy (solid) | 161 (13.6) |
| Malignancy (blood) | 23 (1.9) |
| Metastatic tumor | 26 (2.2) |
| Mild liver disease | 46 (3.9) |
| Moderate to severe liver disease | 26 (2.2) |
| AIDS | 1 (0.1) |
| CCI | |
| 0 | 391 (33.0) |
| 1–2 | 542 (45.8) |
| 3–4 | 182 (15.4) |
| > 4 | 69 (5.8) |
| ADL | |
| Dependent | 288 (24.3) |
| Suspected site of infection | |
| Lung | 367 (31.0) |
| Abdomen | 311 (26.3) |
| Urinary tract | 218 (18.4) |
| Soft tissue | 117 (9.9) |
| Central nervous system | 23 (1.9) |
| IV catheter | 22 (1.9) |
| Osteoarticular | 21 (1.8) |
| Endocardium | 16 (1.4) |
| Wound | 12 (1.0) |
| Implant device | 8 (0.7) |
| Other | 69 (5.8) |
| Positive blood cultures | 636 (54.0) |
| Septic shock | |
| Yes | 745 (62.9) |
| Organ dysfunction on arrival | |
| Hypotension | 656 (55.4) |
| Hyperlactatemia (> 2 mmol/L) | 797 (67.3) |
| Acute kidney injury (Cre > 2 mg/dL) | 455 (38.4) |
| Acute lung injury | 442 (37.3) |
| Hyperbilirubinemia (> 2.0 mg/dL) | 204 (17.2) |
| Thrombocytopenia (< 100,000/μL) | 345 (29.1) |
| Coagulopathy (INR > 1.5) | 225 (19.0) |
| ARDSa at 1st day | 193 (18.0) |
| qSOFA score | 2 (1–3) |
| qSOFA ≥ 2 | 800 (69.6) |
| APACHE II score | 23 (17–29) |
| SIRS score | 3 (2–4) |
| SOFA score | 9 (6–11) |
| SOFA score ≥ 2 | 987 (98.6) |
Reported counts (proportions) for categorical variables and median (interquartile range) for continuous variables
Missing data: body mass index (BMI) = 26, admission source = 2, insurance = 2, activities of daily living (ADL) = 2, blood culture = 7, acute respiratory distress syndrome (ARDS) = 112, quick Sepsis-related Organ Failure Assessment (qSOFA) = 35, Acute Physiology and Chronic Health Evaluation (APACHE) II = 162, systemic inflammatory response syndrome (SIRS) = 43, SOFA = 183
ED emergency department, CCI Charlson Comorbidity Index, COPD chronic obstructive pulmonary disease, AIDS acquired immune deficiency syndrome, IV intravenous
aARDS was defined by Berlin criteria