Table 4.

Association of Baseline Blood Biomarkers and δ Changes at 8 Weeks with Overall Survival

	Baseline		δ at 8 Weeks
Biomarker	HR (95% CI) N = 157	P value	HR (95% CI) N = 124	P value
WBC	1.04 (1.00, 1.09)	0.043	1.18 (1.09, 1.27)	< 0.001
ANC	1.05 (1.01, 1.10)	0.029	1.19 (1.10, 1.28)	< 0.001
ALC	0.81 (0.53, 1.24)	0.33	0.95 (0.51, 1.76)	0.87
ANC:ALC	1.05 (1.03, 1.07)	< 0.001	1.07 (1.04, 1.11)	< 0.001
AMC	1.82 (1.07, 3.09)	0.027	1.45 (0.70, 3.01)	0.31
AEC	0.33 (0.07, 1.52)	0.15	1.51 (0.55, 4.10)	0.42
Platelets (per 50 unit increase)	1.08 (0.98, 1.18)	0.13	1.31 (1.12, 1.53)	< 0.001

HR, 95% CI and P values result from single variable (i.e. unadjusted) Cox proportional hazard models