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. 2018 Nov 23;24:59. doi: 10.1186/s10020-018-0060-3

Fig. 2.

Fig. 2

AGE signaling cascade implicated in the development of CAD. Both endogenous and exogenously derived AGEs are involved in a cycle of formation and degradation. AGEs are recognized by two different classes of receptors which either activate or suppress the generation of reactive oxidative species. Oxidative stress leads to activation of NFκβ with multiple effects on vessel function which contribute to the development of CAD

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