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. 2018 Nov 22;19:450. doi: 10.1186/s12859-018-2456-z

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Example of the assessment of statistical significance for a compatibility score in the histogram of a null distribution (N=10k). Observed compatibility score at the site i was 12800, among pairs selected upstream and downstream sites. Distribution shows scores from randomly selected pairs in window of [ i−w, i+w]. The p-value in this case is 0.0092 (at the tail)