Table 3.
Diagnostic performance of pleural fluid presepsin based on the ROC analysis (n = 132)
| Optimal cut-off point (pg/mL) | Sensitivity (%) | Specificity (%) | +LR | −LR | PPV (%) | NPV (%) | AUC | Accuracy (%) | |
|---|---|---|---|---|---|---|---|---|---|
| Emp vs. other | ≥754 | 90.9 | 74.4 | 1.39 | 0.12 | 24.4 | 98.9 | 0.809 | 75.8 |
| Emp and PE vs. other | ≥680 | 85.2 | 74.3 | 3.31 | 0.20 | 46.0 | 95.1 | 0.803 | 76.5 |
| Emp, PE, and TB vs. other | ≥680 | 66.7 | 72.9 | 2.46 | 0.46 | 48.0 | 85.4 | 0.728 | 71.2 |
| PE vs. other (excluding Emp) | ≥680 | 81.3 | 74.3 | 3.16 | 0.25 | 32.5 | 96.3 | 0.785 | 75.2 |
| Infectious vs. non-infectious | ≥680 | 68.4 | 74.5 | 2.68 | 0.42 | 52.0 | 85.4 | 0.746 | 72.7 |
Emp empyema, PE parapneumonic effusions, TB tuberculosis, +LR positive likelihood ratio, −LR negative likelihood ratio PPV positive predictive value, NPV negative predictive value, AUC area under the curve