Table 3.
Analysis of associations between TGFB codon 10 T/C and codon 25G/C polymorphisms and risk of HAM/TSP development
| Polymorphisms | HAM/TSP | Asymptomatic | ||
|---|---|---|---|---|
| n (%) | n (%) | OR (IC:95%) | p-value | |
| TGFB Codon 10 | ||||
| T/T | 25 (37.3) | 24 (28.9) | 1 | |
| T/C | 29 (43.3) | 45 (54.2) | 0.62 (0.3–1.28) | |
| C/C | 13 (19.4) | 14 (16.9) | 0.89 (0.35–2.29) | 0.61 |
| Alleles | ||||
| T | 79 (59.0) | 93 (55.4) | 1 | |
| C | 55 (41.0) | 73 (43.5) | 0.89 (0.56–1.41) | 0.70 |
| TGFB Codon 25 | ||||
| G/G | 56 (83.6) | 71 (85.5) | 1 | |
| G/C | 10 (14.9) | 11 (13.3) | 1.15 (0.45–2.92) | |
| C/C | 1 (1.5) | 1 (1.2) | 1.27 (0.05–32.54) | 0.74 |
| T/C G/G High | 47 (70.1) | 58 (69.9) | 1 | |
| T/C G/C; C/C G/G; T/T G/C Intermediate | 15 (22.4) | 24 (28.9) | 0.77 (0.36–1.62) | |
| C/C G/C; C/C C/C; T/T C/C Low | 5 (7.5) | 1 (1.2) | 6.17 (0.95–120.4) | 0.51 |
HAM/TSP HTLV-1 associated myelopathy tropical spastic paraparesis, Asymptomatic HTLV-1 patients, OR odds ration with confident interval, Chi-square 2 × 2 or 3 × 2 contingent tables, Fisher exact or Cochran-Armitage tests