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Magnetic resonance imaging scan of a 1-year-old girl with Van der Knaap disease (megaloencephalic leukodystrophy with subcortical cysts). T2-weighted axial images (a and b) show diffuse white matter hyperintensities with swollen appearance of the brain parenchyma with cyst formation at the temporal poles which is better appreciated on the fluid-attenuated inversion recovery image (arrows in c). (Dr. Atin Kumar, Professor, Department of Radiology, AIIMS, New Delhi, India).
