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. 2018 Nov 16;9:2613. doi: 10.3389/fimmu.2018.02613

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Copyright © 2018 Yang, Liu, Sun, Li, Tan, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutralization and ADCC activity of IgG E10 and its binding to MPER peptide F7. (A) Infection inhibition percentage of IgG b12 and E10 against 6 pseudo type HIV strains at different concentrations were shown, calculated IC50 in μg/ml were labeled after the strain and clade names. (B) IgG1 E10, 2F5, and mz76 mediated cellular cytotoxicity against HIV envelope expressing TF228 at different concentrations (μg/ml) were shown by percentage. Experiments were repeated three times. (C) Affinity detection of IgG E10, 2F5, and b12 to MPER peptide fusion protein F7-Fc by ELISA; OD450 at different antibody concentration were shown. (D) FlowJo generated figure showing binding of E10 SCFV expression yeast clone with bal gp120-Fc and F7-Fc fusion proteins, APC positive population indicate positive binding. Statistical analysis, ^**P ≤ 0.01.