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. 2018 Nov 16;9:2583. doi: 10.3389/fimmu.2018.02583

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Copyright © 2018 Wang, Li, Meng, Duan, Wang, Chen, Tang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Immunohistochemistry revealed a large number of atypical lymphoid cells expressing CD2 (A: 20X10), CD3 (B: 20X10), CD4(C: 20X10) and CD7 (E: 20X10). CD5 (D: 20X10)-positive cells were less than CD3-positive cells; CD8 (F: 20X10)-positive cells were less than CD4-positive cells and CD20 (G: 20X10)-positive cells presented a focal distribution. Granzyme B (H: 20X10)-positive cells were scattered. There was partial positivity for TIAI (J: 20X10), TCRGβ, and TCRγδ. Cells were negative for CD56 and Ki-67 (I: 20X10)-positivity was 40–50%. (B) EBV in situ hybridization for EBV encoded mi-RNA (EBER) demonstrated EBV-positive (50/HPF) atypical lymphoid cells (K: 20X10).