Shear stress (or shear force) |
Shear stress is the tangential force applied by a flowing fluid on the surface of an object |
Catch bond/Slip bond |
A catch bond is a bond that becomes stronger (increased lifetime) when a pulling force is applied to it. By contrast, a slip bond becomes weaker (decreased lifetime) with applied force |
Mechanosensing |
Mechanosensing is the process through which cells or proteins detect and respond to variations of forces and mechanical properties of their environment |
Mechanosensor |
A mechanosensor is a molecule/protein that mediates mechanosensing |
Passive mechanosensing |
During passive mechanosensing, a mechanosensor detects applied mechanical stimuli (without applying force or tension itself) |
Active touch sensing |
Active touch sensing is the process through which cells actively probe the mechanical properties of their environment (for instance substrate stiffness) |
Mechanotransduction |
Mechanotransduction is the process during which mechanosensors translate mechanical inputs into intracellular signaling events |
Stiffness (or elastic modulus) |
Stiffness is a measure of the ability of an object or a substance to resist deformation upon an applied force |
Durotaxis |
Migrating cells can sense stiffness of the substrate they migrate in or on, typically via active touch sensing. Durotaxis is the ability of cells to move up rigidity gradients. |