Table 1.
Characteristics of lung cancers
| Characteristics | Entire cohort (n=2,222) | COPD (n=724) | Non-COPD (n=1,498) | P-valuea |
|---|---|---|---|---|
|
| ||||
| Age, years (mean ± SD) | 60.2±9.5 | 62.6±8.5 | 59.1 ±9.7 | <0.001 |
| Sex, n (%) | <0.001 | |||
| Male | 1,670 (75.2) | 636 (87.8) | 1,034 (69.0) | |
| Female | 552 (24.8) | 88 (12.2) | 464 (31.0) | |
| BMI, kg/m2 (mean ± SD) | 24.2±3.5 | 23.7±3.5 | 24.5 ±3.4 | <0.001 |
| Smoking status, n (%) | <0.001 | |||
| Current and ex-smokers | 1,187 (53.4) | 499 (68.9) | 688 (45.9) | |
| Nonsmokers | 1,035 (46.6) | 225 (31.1) | 810 (54.1) | |
| Histology, n (%) | ||||
| Squamous carcinoma | 792 (35.6) | 341 (47.1) | 451 (30.1) | <0.001 |
| Adenocarcinoma | 1,120 (50.4) | 263 (36.3) | 857 (57.2) | <0.001 |
| SCLC | 152 (6.8) | 65 (9.0) | 87 (5.8) | 0.004 |
| LCLC | 78 (3.5) | 31 (4.3) | 47 (3.1) | 0.107 |
| Other subtypesb | 80 (3.6) | 24 (3.3) | 56 (3.7) | 0.356 |
| Treatment, n (%) | ||||
| Surgery | 1,821 (82.0) | 549 (75.8) | 1,272 (84.9) | <0.001 |
| Nonsurgery | 401 (18.0) | 175 (24.2) | 226 (15.1) | |
| Chemotherapy and/or radiotherapy | 327 (14.7) | 139 (19.2) | 188 (12.6) | <0.001 |
| Palliative therapy | 74 (3.3) | 36 (5.0) | 38 (2.5) | <0.001 |
| Clinical stage, n (%) | ||||
| I | 1,598 (71.9) | 531 (73.3) | 1,067 (71.2) | 0.314 |
| II | 463 (20.9) | 152 (21.0) | 311 (20.8) | 0.911 |
| III–IV | 161 (7.2) | 41 (5.7) | 120 (8.0) | 0.045 |
| FVC, L (mean ± SD) | 3.3±0.8 | 3.2±0.7 | 3.4 ±0.8 | <0.001 |
| FVC% predicted, % (mean ± SD) | 101.59±16.8 | 96.1±18.0 | 104.6 ±15.5 | <0.001 |
| FEV1, L (mean ± SD) | 2.5±0.7 | 2.0±0.5 | 2.7 ±0.6 | <0.001 |
| FEV1 predicted, % (mean ± SD) | 95.0±20.3 | 76.5±16.9 | 103.9 ±15.2 | <0.001 |
| FEV1/FVC, % (mean ± SD) | 73.5±9.8 | 61.9±6.4 | 79.2 ±5.1 | <0.001 |
| COPD | ||||
| No | 1,498 (67.4) | / | 1,498 (100) | |
| Yes | 724 (32.6) | 724 (32.6) | / | |
| COPD severity, n (%) | ||||
| Mild | 540 (24.3) | 540 (74.6) | / | |
| Moderate | 155 (7.0) | 155 (21.4) | / | |
| Severe/extremely severe | 29 (1.3) | 29 (4.0) | / | |
| COPD phenotype, n (%) | ||||
| Emphysema-predominant | 75 (3.4) | 75 (10.4) | / | |
| Nonemphysema-predominant | 581 (26.1) | 581 (80.2) | / | |
| Unclassified | 68 (3.1) | 68 (9.4) | / | |
Notes:
a
Comparison between COPD and non-COPD.
b
Other subtypes including adenosquamous, carcinoma carcinoid tumors, sarcomatoid carcinoma, and pulmonary melanoma./, not applicable.
Abbreviations: BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; LCLC, large cell lung cancer; SCLC, small cell lung cancer.