Table 1.
Demographic and clinical characteristics of participants with pulmonary hypertension and controls
| PH | COPD-PH | IPAH | PAH-CTD | CTEPH | Healthy controls | |
|---|---|---|---|---|---|---|
|
| ||||||
| Patients, n | 73 | 27 | 15 | 13 | 18 | 32 |
| Age (years) | 59 (47–67)* | 64.3 (5.3) | 40.8 (10.9)* | 45.7 (9.9)* | 65.8 (7.5) | 63.9 (6.8) |
| Female sex, n (%) | 44 (60) | 12 (44) | 11 (73) | 11 (85)* | 10 (56) | 17 (53) |
| BMI (kg/m2) | 27.5 (2.8) | 27.6 (3.1) | 26.9 (2.4) | 26.5 (2.0) | 28.8 (3.0) | 27.8 (2.5) |
| eGFR (mL/min/1.73 m2) | 60.9 (20.9)* | 64.1 (20.2)* | 66.6 (18.8) | 53.9 (21.3)* | 56.6 (22.5)* | 78.2 (14.8) |
| CRP (mg/L) | 33.8 (20.3)* | 42.5 (18.9)* | 20.7 (11.9) | 46.8 (23.7)* | 22.3 (11.9) | 16.5 (7.8) |
| PaO2 (mm Hg) | 66.2 (10.0)* | 62.1 (8.1)* | 73.8 (11.7)* | 70.0 (9.3)* | 63.3 (7.4)* | 85.9 (5.4) |
| PaCO2 (mm Hg) | 46.7 (9.9)* | 54.9 (10.0)* | 38.9 (36.9–44.9) | 41.2 (5.1) | 40.6 (37.8–48.1) | 40.2 (38.8–44.8) |
| FEV1 (% predicted) | 71.7 (24.6)* | 43.2 (11.0)* | 88.1 (9.3) | 86.7 (12.4) | 89.9 (12.5) | 97.1 (5.6) |
| FVC (% predicted) | 85.1 (16.0)* | 70.5 (12.5)* | 90.8 (9.5) | 94.2 (9.1) | 95.6 (12.8) | 100.7 (8.4) |
| FEV1/FVC (%) | 75.4 (52.6–82.3)* | 45.7 (40.6–57.8)* | 80.6 (6.2) | 79.6 (5.8) | 80.7 (6.0) | 84.6 (78.2–87.7) |
| DLCO (% predicted) | 71.5 (13.0)* | 58.2 (7.9)* | 80.9 (6.5)* | 83.4 (6.8) | 75.0 (8.2)* | 91.1 (6.4) |
| mPAP (mm Hg) | 45.3 (36.7–59.8) | 36.2 (6.9) | 65.5 (20.2) | 58.5 (15.4) | 52.0 (14.8) | – |
| PCWP (mm Hg) | 10.9 (9.1–13.4) | 11.0 (2.8) | 10.3 (2.5) | 12.2 (2.7) | 10.8 (3.0) | – |
| mRAP (mm Hg) | 8.5 (2.4) | 9.3 (2.1) | 8.9 (2.6) | 7.5 (2.1) | 7.9 (2.5) | – |
| CI (L/min/m2) | 2.8 (0.4) | 3.0 (0.4) | 2.6 (0.6) | 2.7 (0.5) | 2.9 (0.3) | – |
| PVR (WU) | 7.9 (4.0) | 4.1 (1.0) | 10.7 (3.3) | 9.7 (2.7) | 10.4 (2.8) | – |
Note: Data are shown as mean (SD) or median (interquartile range),
P<0.05 compared with healthy controls.
Abbreviations: CI, cardiac index; COPD-PH, chronic obstructive pulmonary disease-related pulmonary hypertension; CRP, C-reactive protein; CTEPH, chronic thromboembolic pulmonary hypertension; DLCO, diffusion capacity for carbon monoxide; eGFR, estimated glomerular filtration rate; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; IPAH, idiopathic pulmonary arterial hypertension; mPAP, mean pulmonary arterial pressure; mRAP, mean right atrial pressure; PAH-CTD, connective tissue disorder-associated pulmonary arterial hypertension; PaCO2, partial pressure of arterial carbon dioxide; PaO2, partial pressure of arterial oxygen; PCWP, pulmonary capillary wedge pressure; PH, pulmonary hypertension; PVR, pulmonary vascular resistance; WU, Wood units.