Figure 2.

The effects of crocetin on MPR1 (A) and MPR2 (B) mRNA expression in the A2780-RCIS cell line. The cells were incubated with different concentrations of crocetin (0-200 µM) at 37 ^°C for 48 hr. Effects of crocetin on MRP1 and MRP2 mRNA were evaluated by the Real-time RT-PCR. Each experiment was repeated independently three times and data are shown as mean±SEM. *P≤ 0.05; **P≤ 0.01 vs. control