Figure 3.

The direct (A) and indirect (B) effects of crocetin on the function of MRP transporters in A2780 cell line. The cells were incubated with different concentrations of crocetin (0-200 µM) at 37 °C for 1 to 48 hr. Inhibition effect was evaluated by the drug efflux assay. Each experiment was repeated independently three times in triplicate tests and data are shown as mean±SEM. *P≤0.05; **P≤0.01; ***P≤ 0.001 vs. control