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Nodular melanoma with a central necrosis in the TiO2+laser group. (A, B, C): histopathology of the skin (X40, H&E (A)), (X100, H&E (B, C)). (D): TiO2-PEG NPs present in the necrotic areas (X400, H&E). Accordingly, a severe necrosis was seen in the TiO2+laser group
