Table 2.
The antibiotic susceptibility and resistance mechanism of 26 LZR-Efa
| Isolates | OXA | CFZ | CXM | ERY | CLI | LVX | MXF | TC | TGC | AMK | FM | SXT | LZ | VAN | DAP | RIF | MLST | optrA | 23S rRNA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6,888 | 8 | 32 | 32 | >32 | >32 | 1 | 0.5 | >32 | 1 | >32 | 64 | >8/152 | 8 | 1 | 8 | 2 | 16 | Ile86Arg, Glu238Lys, Pro463Thr | – |
| 8,714 | 8 | 16 | 8 | 1 | 8 | 2 | 1 | 1 | 0.25 | >32 | 32 | 0.25/4.75 | 8 | 1 | 8 | >4 | 674 | NA | Glu26Gln, Leu221Val, Glu260Lys |
| 10,938 | 8 | 32 | 32 | >32 | >32 | >32 | 32 | >32 | 1 | >32 | 32 | >8/152 | 8 | 1 | 4 | 2 | 16 | – | – |
| 11,340 | 8 | 32 | >32 | >32 | >32 | >32 | 32 | >32 | 0.5 | >32 | 64 | >8/152 | 16 | 1 | 4 | 1 | 476 | – | – |
| 11,382 | 8 | 32 | 16 | >32 | >32 | >32 | 16 | >32 | 1 | >32 | 64 | <0.015/0.25 | 8 | 1 | 2 | 1 | 856a | Asp158Tyr, Pro463Thr | Leu156Phe, Arg172Gln |
| 12,654 | 8 | 16 | 16 | 2 | 32 | 2 | 1 | 1 | 0.5 | >32 | 32 | 2/38 | 8 | 2 | 2 | >4 | 857a | NA | Val30Leu, Gly57Ser, Pro236Ser, Ile269Val |
| 13,470 | 16 | 32 | >32 | >32 | >32 | >32 | 16 | >32 | 0.5 | >32 | 64 | >8/152 | 8 | 1 | 4 | 1 | 480 | Asp158Tyr, Pro463Thr | Thr95Ile, Glu260Lys |
| 13,484 | 16 | 32 | >32 | >32 | >32 | 4 | 1 | >32 | 1 | >32 | 32 | >8/152 | 8 | 2 | 8 | 2 | 21 | Asp158Tyr, Pro463Thr | Val30Leu, Gly57Ser, Pro236Ser, Ile269Val |
| 14,980 | 16 | 32 | >32 | >32 | >32 | >32 | 16 | >32 | 0.5 | >32 | 64 | >8/152 | 8 | 1 | 4 | 0.5 | 585 | – | Arg172Gln, Pro236Ser |
| 15,224 | 8 | 16 | >32 | >32 | >32 | 32 | 16 | 32 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 2 | 1 | 16 | Asp158Tyr, Pro463Thr | – |
| 15,407 | 8 | 16 | 32 | >32 | >32 | 1 | 0.25 | 1 | 0.25 | >32 | 64 | 0.25/4.75 | 8 | 0.5 | 4 | 2 | 479 | NA | Pro81Ser, Ala177Ser |
| 15,814 | 8 | 32 | 16 | >32 | >32 | 1 | 0.5 | >32 | 1 | >32 | 32 | >8/152 | 8 | 1 | 4 | 1 | 16 | Ile86Arg, Glu238Lys, Pro463Thr | – |
| 17,838 | 16 | 32 | >32 | >32 | >32 | 32 | 8 | >32 | 0.5 | >32 | 8 | 0.25/4.75 | 8 | 1 | 4 | 2 | 480 | – | Thr95Ile, Glu260Lys |
| 18,026 | 16 | 32 | >32 | >32 | >32 | 32 | 16 | >32 | 0.5 | >32 | 32 | 0.0315/0.59375 | 8 | 1 | 4 | 4 | 476 | – | – |
| 19,663 | 16 | 32 | >32 | >32 | >32 | 32 | 8 | >32 | 0.5 | >32 | 64 | >8/152 | 8 | 1 | 2 | 2 | 480 | Asp158Tyr, Pro463Thr | Thr95Ile, Glu260Lys |
| 19,910 | 16 | 32 | >32 | >32 | >32 | 16 | 4 | >32 | 0.5 | >32 | 32 | >8/152 | 8 | 2 | 4 | >4 | 116 | Asp158Tyr, Pro463Thr | Arg172Gln |
| 23,903 | 16 | 32 | >32 | >32 | >32 | >32 | 16 | >32 | 0.5 | >32 | 64 | >8/152 | 8 | 1 | 4 | 0.5 | 585 | Pro463Thr, Ile604Met | Arg172Gln, Pro236Ser |
| 23,967 | 16 | 32 | >32 | >32 | >32 | >32 | 16 | >32 | 0.5 | >32 | 64 | >8/152 | 8 | 1 | 4 | 0.5 | 585 | Pro463Thr, Ile604Met | Arg172Gln, Pro236Ser |
| 24,393 | 8 | 16 | 16 | 2 | 32 | 1 | 0.5 | >32 | 0.5 | >32 | 32 | 0.0625/1.1875 | 16 | 1 | 4 | 4 | 81 | Asp158Tyr, Pro463Thr | Glu154Gln, Pro236Ser, Ile269Val |
| 26,167 | 8 | 16 | 16 | >32 | >32 | 1 | 0.5 | >32 | 1 | >32 | 64 | <0.015/0.25 | 8 | 1 | 2 | 2 | 619 | Asp158Tyr, Pro463Thr | Glu154Gln, Pro236Ser, Ile269Val |
| 27,149 | 8 | 32 | 32 | >32 | >32 | >32 | 32 | 1 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 4 | 2 | 858a | Asp158Tyr, Pro463Thr | – |
| 27,451 | 16 | 32 | >32 | >32 | >32 | >32 | 16 | >32 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 4 | 0.25 | 585 | – | Arg172Gln, Pro236Ser |
| 31,890 | 16 | 32 | >32 | >32 | >32 | >32 | 32 | >32 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 8 | 4 | 585 | Pro463Thr, Ile604Met | Arg172Gln, Pro236Ser |
| 32,142 | 8 | 32 | 16 | >32 | >32 | >32 | 32 | >32 | 0.5 | >32 | 128 | >8/152 | 8 | 1 | 4 | 1 | 16 | Asp158Tyr, Pro463Thr | – |
| 32,633 | 16 | 32 | 32 | >32 | >32 | >32 | 32 | >32 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 4 | 1 | 476 | Asp158Tyr, Pro463Thr | – |
| 33,710 | 8 | 32 | 32 | >32 | >32 | >32 | 32 | >32 | 0.5 | >32 | 32 | >8/152 | 8 | 1 | 4 | 1 | 16 | Asp158Tyr, Pro463Thr | – |
Note:
a
New ST types.
Abbreviations: AMK, amikacin; CFZ, cefazolin; CLI, clindamycin; CXM, cefuroxime; DAP, daptomycin; ERY, erythromycin; FM, fosfomycin; LVX, levofloxacin; LZ, linezolid; LZR-Efa, linezolid-resistant Enterococcus faecalis; MLST, multilocus sequence typing; MXF, moxifloxacin; NA, not available; OXA, oxacillin; RIF, rifampin; SXT, trimethoprim-sulfamethoxazole; TC, tetracycline; TGC, tigecycline; VAN, vancomycin.