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. 2018 Nov 20;13:7711–7725. doi: 10.2147/IJN.S182428

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© 2018 Rosenbrand et al. This work is published and licensed by Dove Medical Press Limited

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Organic surface modifications increased MSN labeling efficiency in hMSCs.

Notes: (A) High uptake of MSNs, MSN-Lip, MSN-Lip-PEG_2,000, and MSN-PEG_2,000, but not MSN-PEG₇₅₀ in hMSCs (D133A) cells after exposure for 2 hours using flow-cytometry analysis. (B) MSN uptake after longer exposure (24 and 48 hours) using flow cytometry: MSN-Lip uptake remained stable, and increased particle uptake was observed for unfunctionalized and PEGylated MSNs in donor D133A (left graph). This was reproducible in the same donor (middle graph), and a similar cell-internalization trend was observed in a different hMSC donor (D313 right graph).

Abbreviations: hMSC, human mesenchymal stem cell; Lip, lipid; MSNs, mesoporous silica nanoparticles; PEG, polyethylene glycol.