Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 20;13:7711–7725. doi: 10.2147/IJN.S182428

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Rosenbrand et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Mass-spectrometry-based label-free quantitative proteomics of hMSCs exposed to surface functionalized MSNs.

Notes: The proteome of hMSCs exposed for 24 hours to unfunctionalized and functionalized MSNs (MSN-Lip, MSN-Lip-PEG_2,000, MSN-PEG_2,000, and MSN-PEG₇₅₀) was analyzed. (A) Principal-component analysis showing the similarity of protein profiles across samples and abundance in variation between the samples: no separation of MSN-labeled cells or control cells in PC1; however a clear distinction between MSN-, MSN-Lip-, and MSN-PEG₇₅₀-labeled cells and control cells was visible on PC2. Summary of significantly upregulated (B) and downregulated (C) proteins, which were mostly specific for the differently surface-modified MSNs.

Abbreviations: hMSC, human mesenchymal stem cell; Lip, lipid; MSNs, mesoporous silica nanoparticles; PEG, polyethylene glycol.