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. 2018 Nov 20;13:7727–7747. doi: 10.2147/IJN.S182384

Figure 4.

Figure 4

Delivery of LNA-anti-miR-142-3p to the 4T1 and TUBO breast cancer cell lines via exosomes.

Notes: (A) qRT-PCR analysis of relative expression of miR-142-3p (i) and APC mRNA (ii) levels in 4T1 and TUBO cells untreated or treated with unloaded exosomes, exosomes loaded with LNA-anti-miR-142-3p, or exosomes loaded with anti-miR negative control, normalized to U6 snRNA. (B) qRT-PCR analysis of relative expression of miR-150 (i) and P2X7R mRNA (ii) levels in 4T1 and TUBO cells treated as indicated. The data are presented as mean ± SEM (*P<0.05 vs untreated or treated with unloaded exosomes and anti-miR negative control loaded exosomes).

Abbreviations: LNA, locked nucleic acid; snRNA, small nuclear ribonucleic acid; NC loaded exosomes, exosomes loaded with LNA-anti-miR negative control; qRT-PCR, quantitative real-time PCR; SEM, standard error of the mean.