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. 2018 Nov 20;13:7727–7747. doi: 10.2147/IJN.S182384

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© 2018 Naseri et al. This work is published and licensed by Dove Medical Press Limited

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In vivo MSCs-derived exosomes biodistribution in tumor-bearing mice by animal imaging.

Notes: (A) BALB/c mice bearing TUBO tumor received intravenous injections of 30 µg PKH67-labeled exosomes collected from bone marrow-derived MSCs to evaluate whether MSCs-Exo can migrate to the tumor site. The fluorescent signal was monitored at 3, 12, 24, and 48 hours after the intravenous injection of fluorescently labeled MSCs-Exo using IVIS. The tumor sites in the images are marked by a red circle. (B) Control BALB/c mouse received intravenous injection of 30 µg PKH67-labeled MSCs-Exo and was imaged immediately after injection.

Abbreviations: IVIS, in vivo imaging system; MSCs-Exo, mesenchymal stem cells-derived exosomes.