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. 2018 Nov 19;13:7623–7631. doi: 10.2147/IJN.S179226

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© 2018 Huang et al. This work is published and licensed by Dove Medical Press Limited

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(A) In vitro cellular killing efficiency of TNP/DOX/ZnPC with laser irradiation at different weight ratios of DOX and ZnPC determined by MTT assay at 24 hours.

Notes: Concentrations of TNP were equal to the amount of TNP in corresponding drug-loaded group. (B) Cellular ROS generation assay of free ZnPC and TNP/DOX/ZnPC with weight ratio of DOX:ZnPC=1:5 in 5637 cells at 4 hours postincubation. Laser irradiation was 100 J/cm², 660 nm, 120 seconds. (n=6, ***P<0.001.)

Abbreviations: DOX, doxorubicin; TNP, thermal-responsive nanoparticle; ZnPC, zinc phthalocyanine; TNP/DOX/ZnPC, mixture of equivalent mole of TNP/DOX and TNP/ZnPC.