Figure 6.

(A) Diclofenac sodium flux into skin cultures vs ultrasound parameter configuration. (B) Concentration of diclofenac sodium permeated vs time at various ultrasound amplitudes. (C) Histological image of skin culture insonified with 20 kHz continuously with a duty factor of 20% for 5 minutes.³²

Note: Reproduced from Ultrason Sonochem, 22, Aldwaikat M, Alarjah M. Investigating the sonophoresis effect on the permeation of diclofenac sodium using 3D skin equivalent, 580–587. Copyright (2015), with permission from Elsevier.