Figure 1: Tumor microenvironment of pancreatic cancer contains abundant macrophages.
Elevated macrophages are seen in the microenvironment as determined by (A) immunohistochemistry (IHC) for the macrophage marker F4/80. (B) Flow cytometry for CD45+CD3−CD11b+F4/80+cells confirms decrease in macrophages after diphtheria toxin treatment in CD11b-DTR mice. (C,D) Results were confirmed by IHC for F4/80.