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Frataxin knockdown in healthy fibroblasts decreases mitochondrial DNA copy number. Human fibroblast cells are treated with FXN siRNA and CTL siRNA. (A) qPCR analysis of mt/nDNA ratio 5 days post transfection in GM3440 and GM8402. (B) qPCR analysis of mt/nDNA ratio at different time points in GM3440. Bars represent averages ± standard deviations (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001).
