TABLE 1.
Cell Types of the VZ in Human Fetuses
Cell Type | Function | Basal Process | Cilia | Immuno-histochemical Markers | Predominant Ventricle Wall Locationa | Figures |
---|---|---|---|---|---|---|
1 | Uncommitted NSCb | Long radial | One | GFAP+, AQP 4+, βIV-tub- | Lateral and dorsal | 2, 7, Sup 2–5 |
2 | Early pre-ependymal NSC | Long radial | One | GFAP+, βIV-tub+ | Lateral and dorsal | 7, Sup 2, 3 |
3 | Late pre-ependymal NSC | Long radial | One | GFAP-, βIV-tub+ | Lateral and dorsal | 2, 7, Sup 3 |
4 | Committed early ependyma | Short | None | GFAP+, βIV-tub+ | Lateral and medial | 6, 7, Sup 2 |
5 | Immature ependyma | Short | Multi | GFAP+, βIV-tub+ | Medial | 6, Sup 2–5 |
6 | Immature ependyma | Short | Multi | GFAP−, βIV-tub+ | Medial | 6, 7, Sup 4 |
7 | Mature ependyma | None | Multi | GFAP−, βIV-tub+ | Medial | 7, Sup 5 |
During the second half of gestation.
NSC, also regarded as radial glia.
GFAP+, glial fibrillary acidic protein-positive; βIV-tub+, βIV-tubulin-positive. βIV-tubulin is a component of the cilium microtubules. Sup, Supplementary Data figures.