TABLE 2.
Case Histories Listed by Increasing IVH Scores
| Case no. | Condition | EGA birth in weeks | Survival in days | US days postbirth | HMG, days duration | FOHR | Neuropathologic Findings from Clinical Recordsa |
|---|---|---|---|---|---|---|---|
| 1 | Control | 23 3/7 | 0 | NA | None | NA | No HMG, PDA, PFO, abnormal lobation right and left lung, large right pneumothorax, no gross brain abnormality, placental abruption likely the cause of all pathology |
| 2 | Control | 24 | 0 | NA | None | 0.50 | No HMG, subpulmonary pneumothorax |
| 3 | Control | 25 1/7 | 8 | NA | None | 0.49 | Sepsis, normal brain, severe mixed respiratory and metabolic acidosis |
| 4 | IVH-1 | 27 5/7 | 12 | 10 | 2–12 | 0.48 | Germinal matrix/parenchymal HMG |
| 5 | IVH-1 | 35 | 32 | 9 and 29 | 28–32 | 0.40 | Abnormal karyotype, initial IVH-1, small right subependymal hemorrhage, later normal on US |
| 6 | IVH-1 | 38 1/7 | 41 | 8 and 42 | 37–45 | 0.44 | HIE, initial IVH-1 later normal |
| 7 | IVH-1 or 2 | 28 | 2 | 1 and 2 | 1–2 | 0.43 | 402 Kb maternally inherited interstitial deletion on chromosome 12p, diffuse lung injury, pneumopericardium, blood filled cystic right chest wall mass, subependymal and unilateral CP HMG, lymphatic venous malformation = COD, mild dilation posterior horn LV, mild reactive gliosis, periventricular calcifications could be infections |
| 8 | IVH-2 | 23 3/7 | 1 | 0 | 1 | 0.48 | Massive pulmonary HMG, hyaline membrane disease, sepsis |
| 9 | IVH-3 | 29 4/7 | 14 | 2 | 3–16 | 0.46 | HIE, bilateral HMG and small SAH, mild ventriculomegaly |
| 10 | IVH-4 | 23 | 5 | 3 | 2–5 | 0.57 | Respiratory failure, focal acute pneumonia right lung, PDA, PFO |
| 11 | IVH-4 | 24 | 2 | 2 | 0–2 | 0.50 | Diffuse pulmonary HMG = COD, PFO, coagulopathy, subependymal HMG, intracranial bleed |
| 12 | IVH-4 | 27 6/7 | 1 | NA? | 0–1 | 0.39 | Hyaline membrane disease, pulmonary insufficiency, rest of body normally formed, COD = pulmonary consolidation, PFO, IVH in all ventricles |
| 13 | IVH-4 | 28 | 19 | 6 | 13–19 | 0.53 | Respiratory failure and IVH4 = COD, Beckwith-Wiedemann Syndrome, PDA |
| 14 | IVH-4 | NA | NA | NA | NA | NA | Hemodynamic failure = COD. Subependymal HMG in left hemisphere and a massive IVH, IVH-4 determined by neuropathologist; Malaga |
| 15 | IVH-4 | 26 1/7 | 6 | NA | 0–6 | NA | PHH; IVH-3 and 4 in left and right LVs, respectively; periventricular venous infarction; Groningen |
| 16 | IVH-4 | 23 | 0 | NA | NA | NA | IVH-4 determined by neuropathologist; Malaga |
| 17 | SAH | 39 1/7 | 0 | NA | No IVH | NA | Diffuse pulmonary HMG, systemic hypoxia, transposition of great vessels, PDA, PFO, occipital SAH, skull and fontanels normal, cortical convolutions, and SC normal |
a
All from SLCH unless indicate for Groningen and Malaga.
CP, choroid plexus; COD, cause of death; EGA, equivalent/estimated gestational age from menstrual cycle; e.g. 23 3/7 = 23 weeks + 3 days; FOHR, frontal-occipital horn ratio; HIE, hypoxia/ischemia; HMG, hemorrhage; IVH, intraventricular hemorrhage (diagnosed by US); LV, lateral ventricle; NA, not available; PDA, patent ductus arteriosis; PFO, patent foramen ovale; SAH, subarachnoid hemorrhage; SC, spinal cord; US, ultrasound.