TABLE 3.
Plasma vitamin E concentrations and the risk of TB disease among household contacts of index TB1 patients
| Median | Cases/ | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| (range) | controls, n | OR (95% CI) | P | OR2 (95% CI) | P | |
| α-Tocopherol deficient (<5.00 mg/L) | 67/169 | 2.14 (1.46, 3.13) | <0.001 | 1.59 (1.02, 2.50) | 0.04 | |
| α-Tocopherol, mg/L | ||||||
| Tertile 1 (n = 296) | 4.55 (0.18, 5.34) | 76/220 | 1.86 (1.18, 2.92) | 0.01 | 1.29 (0.76, 2.18) | 0.35 |
| Tertile 2 (n = 297) | 6.02 (5.34, 6.86) | 51/246 | 1.01 (0.65, 1.56) | 0.97 | 0.83 (0.51, 1.36) | 0.46 |
| Tertile 3 (n = 296) | 8.33 (6.87, 35.2) | 53/243 | 1.00 | 1.00 | ||
| P-trend = 0.02 | P-trend = 0.36 | |||||
| γ-Tocopherol, mg/L | ||||||
| Tertile 1 (n = 296) | 0.64 (0.10, 0.81) | 68/228 | 1.20 (0.80, 1.80) | 0.37 | 0.86 (0.54, 1.38) | 0.54 |
| Tertile 2 (n = 297) | 0.97 (0.81, 1.16) | 52/245 | 0.85 (0.56, 1.28) | 0.43 | 0.71 (0.44, 1.14) | 0.15 |
| Tertile 3 (n = 296) | 1.47 (1.17, 5.53) | 60/236 | 1.00 | 1.00 | ||
| P-trend = 0.45 | P-trend = 0.55 | |||||
| δ-Tocopherol, mg/L | ||||||
| Tertile 1 (n = 296) | 0.13 (0.04, 0.19) | 72/224 | 2.04 (1.23, 3.36) | 0.01 | 2.29 (1.29, 4.09) | 0.005 |
| Tertile 2 (n = 297) | 0.25 (0.19, 0.34) | 59/238 | 1.35 (0.88, 2.08) | 0.17 | 1.66 (1.01, 2.72) | 0.04 |
| Tertile 3 (n = 296) | 0.49 (0.34, 3.50) | 49/247 | 1.00 | 1.00 | ||
| P-trend = 0.01 | P-trend = 0.005 | |||||
1TB, tuberculosis.
2Adjusted for matching factors (age and sex), vitamin A deficiency, BMI categories, socioeconomic status, heavy alcohol consumption (≥40 g or ≥3 alcoholic drinks/d), tobacco use, isoniazid preventive therapy, TB history, comorbid disease, self-reported diabetes, and index patient smear status; 67 household contacts had missing information on ≥1 covariate.