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HfRPE grown on normal versus abnormal ECM. Brightfield microscopy of hfRPE cells grown for 2 weeks on (A) commercial human ECM, ECM made by (B) ARPE-19 wild-type or (C) ARPE-19-EFEMP1R345/R345W cells. Scale bars 10 µm. (D) TER measured in hfRPE cell cultured on human ECM, ECM made by ARPE-19 wild-type or ARPE-19-EFEMP1R345/R345W cells for 2 weeks (n = 3 cultures/ECM type. t-test, *P < 0.05).
