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Abnormal ECM alters the ECM turnover. (A) MMP-2 activity measured by zymography in apical and basal conditioned media of hfRPE cells cultured on normal (wt) or abnormal (mut) ECM made by ARPE-19-EFEMP1R345/R345W. (B) mRNA levels of MMP-2 measured in the same cultures, normalized to GAPDH (data represented as mean ± SEM; t-test, **P < 0.01; n = 4/ECM type).
