Table 2.
Comparison of the proportion of hemodialysis patients randomized to the high-protein versus low-protein hemodialysis meal groups who achieved a clinically significant change [Δ; defined as the median (IQR) difference in the preintervention value minus the postintervention value) in weight and laboratory characteristics postintervention
| High-protein hemodialysis meal, | Low-protein hemodialysis meal, | P-value* | |
|---|---|---|---|
| % (n) | % (n) | ||
| Δ Serum albumin ≥0.2 (g/dL) | 51 (28) | 29 (15) | 0.024 |
| Δ Phosphorus ≥0.5 (mg/dL) | 31 (17) | 47 (24) | 0.088 |
| Δ Calcium ≥0.5 (mg/dL) | 18 (10) | 16 (8) | 0.732 |
| Δ PTH ≥50 (pg/mL) | 56 (14) | 59 (13) | 0.831 |
| Δ Alkaline Phos. ≥25 (U/L) | 18 (10) | 16 (8) | 0.732 |
| Δ nPCR ≥0.2 (g/kg/day) | 27 (15) | 22 (11) | 0.461 |
| Δ Bicarbonate ≥5 (mEq/L) | 8 (4) | 14 (7) | 0.354 |
| Δ Potassium ≥0.5 (mEq/L) | 20 (11) | 33 (17) | 0.120 |
| Δ Serum creatinine ≥1.0 (mg/dL) | 26 (14) | 19 (9) | 0.387 |
| Δ Blood urea nitrogen ≥20 (mg/dL) | 16 (9) | 16 (8) | 0.924 |
| Δ Serum prealbumin ≥0.2 (mg/dL) | 39 (17) | 34 (16) | 0.649 |
| Δ spKt/V ≥0.2 | 23 (10) | 18 (8) | 0.561 |
| Δ URR ≥10 | 9 (5) | 10 (5) | >0.999 |
| Δ Hemoglobin ≥0.5 (g/dL) | 31 (17) | 36 (18) | 0.581 |
| Δ WBC ≥25 (×109/L) | 0 (0) | 0 (0) | N/A |
| Δ Platelet count ≥50 (×109/L) | 15 (8) | 16 (8) | 0.867 |
| Δ LDL ≥25 (mg/dL) | 18 (8) | 13(6) | 0.504 |
| Δ HDL ≥10 (mg/dL) | 18 (8) | 17 (8) | 0.887 |
| Δ Triglycerides ≥25 (mg/dL) | 38 (17) | 27 (13) | 0.270 |
| Δ TNF-α ≥5 (pg/mL) | 20 (9) | 27 (13) | 0.455 |
| Δ IL-6 ≥5 (pg/mL) | 9 (4) | 31 (15) | 0.010 |
| Δ Leptin ≥10 (ng/mL) | 22 (10) | 18 (9) | 0.642 |
| Δ C-reactive protein ≥1.0 (mg/L) | 9 (4) | 13 (6) | 0.741 |
| Δ Weight ≥5 (kg) | 0 (0) | 4 (2) | 0.229 |
| Δ BMI ≥5 (kg/m2) | 0 (0) | 2 (1) | 0.481 |
PTH, parathyroid hormone; Alkaline Phos., alkaline phosphatase; nPCR, normalized protein catabolic rate; spKt/V, single-pool Kt/V; URR, urea reduction ratio; WBC, white blood cell count; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; BMI, body mass index.
*P-value calculated by χ2 or Fisher's exact test.