Table 4.
Comparison of the change [Δ; defined as the median (IQR) difference in the preintervention value minus the postintervention value) in postintervention weight and laboratory characteristics among hemodialysis patients randomized to the high-protein versus low-protein hemodialysis meal groups
| High-protein hemodialysis meal | Low-protein hemodialysis meal | P-value* | |
|---|---|---|---|
| Δ Serum albumin (g/dL) | 0.2 (−0.1–0.3) | 0.0 (−0.2–0.2) | 0.007 |
| Δ Phosphorus (mg/dL) | −0.4 (−1.2–1.0) | 0.4 (−0.8–1.1) | 0.133 |
| Δ Calcium (mg/dL) | −0.1 (−0.3–0.3) | −0.1–(−0.5–0.3) | 0.732 |
| Δ PTH (pg/mL) | 104 (−64–306) | 73 (4–196) | 0.941 |
| Δ Alkaline Phosphatase (U/L) | 1 (−7–15) | 0 (−10–13) | 0.554 |
| Δ nPCR (g/kg/day) | −0.01 (−0.14–0.25) | −0.02 (−0.17–0.17) | 0.473 |
| Δ Bicarbonate (mEq/L) | −1 (−3–2) | 1 (−2–2) | 0.117 |
| Δ Potassium (mEq/L) | 0.0 (−0.4–0.4) | 0.1 (−0.3–0.6) | 0.211 |
| Δ Serum creatinine (mg/dL) | 0.2 (−0.4–1.0) | −0.4 (−1.2–0.8) | 0.020 |
| Δ Blood urea nitrogen (mg/dL) | 0 (−12–13) | 0 (−7–14) | 0.932 |
| Δ Serum prealbumin (mg/dL) | 1.7 (−4.9–2.2) | −1.4 (−3.3–3.1) | 0.413 |
| Δ spKt/V | −0.01 (−0.14–0.18) | −0.02 (−0.17–0.14) | 0.700 |
| Δ URR | 0 (−3–3) | 0 (−3–2) | 0.893 |
| Δ Hemoglobin (g/dL) | −0.3 (−0.9–0.8) | −0.2 (−1.3–0.8) | 0.815 |
| Δ WBC (×109/L) | 0.4 (−0.2–1.5) | 0.2 (−1.2–1.3) | 0.359 |
| Δ Platelet count (×109/L) | 8 (−19–29) | −9 (−31–18) | 0.057 |
| Δ LDL (mg/dL) | 7 (−12–18) | −4 (−25–13) | 0.103 |
| Δ HDL (mg/dL) | −2 (−10–5) | −1 (−10–7) | 0.988 |
| Δ Triglycerides (mg/dL) | −4 (−35–35) | 2 (−29–26) | 0.930 |
| Δ TNF-α (pg/mL) | 2.01 (−1.37–3.82) | 2.17 (−0.23–5.39) | 0.346 |
| Δ IL-6 (pg/mL) | −0.52 (−3.66–1.70) | 1.07 (−0.56–6.69) | 0.002 |
| Δ Leptin (ng/mL) | 1.1 (−9.7–9.6) | −1.5 (−9.6–5.7) | 0.198 |
| Δ C-reactive protein (mg/L) | 0.07 (0.17–0.38) | 0.00 (−0.18–0.29) | 0.727 |
| Δ Weight (kg) | 0.4 (−0.4–1.4) | 0.7 (−0.8–2.1) | 0.535 |
| Δ BMI (kg/m2) | 0.1 (−0.2–0.5) | 0.3 (−0.3–0.7) | 0.569 |
PTH, parathyroid hormone; nPCR, normalized protein catabolic rate; spKt/V, single-pool Kt/V; URR, urea reduction ratio; WBC, white blood cell count; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; BMI, body mass index.
*P-value calculated by Wilcoxon rank sum test.