Table 2.
Hazard ratios and 95% confidence intervals of all-cause mortality, myocardial infarction and stroke by quartiles of total cholesterol variability (coefficient of variation)
| Events (n) | Follow-up duration (person- years) | Incidence rate (per 1000 person- years) | Adjusted HR (95% CI)a | |
|---|---|---|---|---|
| All-cause mortality | ||||
| Q1 | 18 557 | 7 609 048 | 2.4 | 1 (ref) |
| Q2 | 17 239 | 7 612 608 | 2.3 | 1.03 (1.00–1.05) |
| Q3 | 19 231 | 7 604 753 | 2.5 | 1.08 (1.06–1.10) |
| Q4 | 29 598 | 7 569 197 | 3.9 | 1.26 (1.24–1.28) |
| P for trend | <0.0001 | |||
| Myocardial infarction | ||||
| Q1 | 9294 | 7 574 752 | 1.2 | 1 (ref) |
| Q2 | 9032 | 7 579 280 | 1.2 | 1.02 (0.99–1.05) |
| Q3 | 9667 | 7 569 634 | 1.3 | 1.05 (1.02–1.08) |
| Q4 | 12998 | 7 521 513 | 1.7 | 1.08 (1.05–1.11) |
| P for trend | <0.0001 | |||
| Stroke | ||||
| Q1 | 9632 | 7 576 013 | 1.3 | 1 (ref) |
| Q2 | 9206 | 7 581 311 | 1.2 | 1.05 (1.02–1.08) |
| Q3 | 10008 | 7 570 911 | 1.3 | 1.07 (1.04–1.10) |
| Q4 | 14015 | 7 522 395 | 1.9 | 1.11 (1.08–1.14) |
| P for trend | <0.0001 | |||
a
Adjusted for age, sex, body mass index, alcohol consumption, smoking, regular exercise, income, diabetes mellitus, hypertension, mean total cholesterol level, and use of lipid-lowering agent (model 4). Models 1–3 are presented in the Supplementary material online, Table S3.