TABLE 2.
Results of Neuropathologic Evaluation Using Original Protocol for Retrospective and Prospective Cases
| Neuropathologic Rankings |
Prospective (n) | Retrospective (n) | ||
|---|---|---|---|---|
| AD | LB | MVL | ||
| None/low | None | None | 3 | |
| Moderate | 2a | |||
| Severe | 1 | 4 | ||
| Transitional | Severe | 1 | ||
| Neocortical | None | 2 | ||
| Moderate | 1 | |||
| Intermediate | None | None | 3 | |
| Moderate | 1 | |||
| Severe | 5 | |||
| Transitional | Moderate | 1 | ||
| Neocortical | None | 1 | ||
| Moderate | 3 | |||
| Severe | 1 | |||
| High | None | None | 4 | 2 |
| Moderate | 3 | |||
| Severe | 1 | |||
| Transitional | None | 4 | ||
| Moderate | 1 | |||
| Severe | 1 | |||
| Neocortical | None | 1 | 2 | |
| Not AD | 2b | |||
| Total assessed | 20 | 30 | ||
| Total analyzed | 18 | 28 | ||
aOldest 2 retrospective cases where α-synuclein (LB 509) IHC failed in the Condensed Protocol work up. Both were excluded from analysis
bOne case of Niemann Pick disease and 1 case of progressive supranuclear palsy. Both were excluded from analysis.