Table 3.
Demographic data and non-criteria characteristics of patients with primary systemic vasculitis with available ACR criteria
| Characteristic | Correctly classified by the 1990 ACR criteria | P-valuea | |
|---|---|---|---|
| Yes | Nob | ||
| All patients (n = 944) | 633 (67.1) | 311 (32.9) | |
| Age, mean (s.d.), years | 60.9 (17.6) | 58.1 (17.5) | 0.022 |
| Female, n (%) | 360 (56.9) | 178 (56.6) | 0.944 |
| Large-vessel vasculitis (n = 398) | 319 (80.2) | 79 (19.8) | |
| Age, mean (s.d.), years | 68.5 (15.4) | 63.3 (15.7) | 0.010 |
| LV-GCAc | 5 (1.6) | 26 (32.9) | <0.001 |
| Vascular US performed | 107 (33.5) | 28 (35.4) | 0.749 |
| Positive vascular US | 84 (26.3) | 22 (27.8) | 0.785 |
| PET scan performed | 37 (11.6) | 37 (46.8) | <0.001 |
| Positive PET scan | 21 (6.6) | 31 (39.2) | <0.001 |
| MRA/CTA performed | 63 (19.8) | 26 (32.9) | 0.012 |
| Positive MRA/CTA | 49 (77.8) | 23 (88.5) | 0.005 |
| ANCA-associated vasculitis (n = 448) | 253 (56.5) | 195 (43.5) | |
| Age, mean (s.d.), years | 54.3 (15.2) | 58.2 (16.5) | 0.009 |
| ANCA positive | 221 (87.4) | 171 (87.8) | 0.914 |
| PR3/MPO positive | 218 (86.2) | 161 (82.6) | 0.295 |
| Limited diseased (only GPA and EGPA) | 43 (19.0) | 33 (25.8) | 0.137 |
| Biopsy performed | 193 (76.3) | 139 (71.3) | 0.231 |
| Consistent with vasculitise | 136 (70.5) | 99 (71.2) | 0.881 |
Figures refer to number of patients with characteristic and percentage of group, unless stated otherwise.
Demographics and characteristics between patients with regards to classification by the ACR criteria were analysed using Pearson’s χ2 test or t test for equality of means, as appropriate. All P-values are two-tailed and were considered significant if < 0.05.
Not correctly classified by 1990 ACR criteria means that either they did not meet the criteria or were classified with a vasculitis not concordant with the one submitted by the investigator.
Defined as GCA with clinical or radiologic evidence of large-vessel involvement but without clinical evidence of cranial involvement.
Defined as GPA/EGPA with upper/lower respiratory tract disease without any other systemic involvement or constitutional symptoms.
Based on DCVAS items: biopsy consistent with vasculitis but not definite or definite vasculitis (not necessarily reflecting the ACR-biopsy definitions). CTA: CT-angiography; DCVAS: Diagnostic and Classification Criteria in Vasculitis Study; EGPA: eosinophilic granulomatosis with polyangiitis; GPA: granulomatosis with polyangiiti; IgAV: IgA-vasculitiss; MPA: microscopic polyangiitis; MPO: myeloperoxidase; MRA: MR-angiography; PAN: polyarteritis nodosa; TAK: Takayasu’s arteritis.