Skip to main content
. 2017 Mar 11;32(10):1645–1655. doi: 10.1093/ndt/gfx005

FIGURE 1.

FIGURE 1

Effects of cilastatin on cisplatin-induced nephrotoxicity in rats. Parameters of renal function on day 5 after administration of cisplatin. (A) Serum creatinine, (B) blood urea nitrogen, (C) glomerular filtration rate, (D) renal hypertrophy. Cisplatin administration increases serum creatinine, blood urea nitrogen and renal hypertrophy, and reduces glomerular filtration rate, compared with control groups. Cilastatin significantly improved all the parameters. Results are expressed as mean ± SEM; n = 7–8 animals per group. cil, cilastatin; kidney w/BW, kidney weight:body weight. *P < 0.05 versus control groups; †P ≤ 0.0001 versus cisplatin group; ‡P < 0.05 versus cisplatin group; §P < 0.02 versus all groups.