FIGURE 4.

Effects of cilastatin on cisplatin-induced renal nuclear factor (NF)-κB activation. (A) Representative electrophoretic mobility shift assay experiment from renal tissue. (B) Densitometric analysis of electrophoretic mobility shift assay on kidney tissue. Administration of cisplatin increases NF-κB activity on renal tissue. Cilastatin significantly reduced the increase of NF-κB activity induced by cisplatin. All results are expressed as mean  ±  SEM; n  =  7–8 animals per group. cil, cilastatin. *P  <  0.02 versus all groups.