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. 2017 Mar 11;32(10):1645–1655. doi: 10.1093/ndt/gfx005

FIGURE 7.

FIGURE 7

Effects of cisplatin and cilastatin on renal expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1. Localization of VCAM-1 in kidney sections of (A) control rats, (B) cisplatin, (C) control  +  cilastatin and (D) cisplatin  +  cilastatin. Note increased renal staining in cisplatin-injected rats (arrows) compared with cisplatin  +  cilastatin and control groups (magnification 20×). (E) Semiquantification of VCAM-1 immunostaining in renal cells. (F) Renal mRNA expression of VCAM-1. (G) Renal mRNA expression of ICAM-1. Cilastatin significantly reduced the increase of both VCAM-1 and ICAM-1 mRNA expression induced by cisplatin. All results are expressed as mean  ±  SEM; n  =  7–8 animals per group. cil, cilastatin. *P  ≤  0.001 versus all groups; †P  <  0.05 versus all groups.