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Ch4 subregional spatiotemporal progression of TOC1+ pathology. Histograms (mean ± SEM) of the percentage of TOC1+ neurons (including both p75NTR+/TOC1+ and TOC1+ neurons); (A) and the ratio of TOC1+ neurons to p75NTR+ neurons (B) in each subdivision (anterior, intermediate, posterior) of the CBF by clinical group (NCI, white bars; MCI, gray bars; AD, black bars). *Significant difference between groups (p < 0.05).
