TABLE 1.
Demographic, Clinical, and Neuropathological Characteristics by Diagnosis
| Clinical Diagnosis |
|||||
|---|---|---|---|---|---|
| NCI | MCI | AD | Total | Comparison by Diagnosis Group (p Value) | |
| (n = 12) | (n = 9) | (n = 12) | (n = 33) | ||
| Age at death (years) | |||||
| Mean ± SD | 85.2 ± 4.4 | 87.5 ± 4.9 | 88.2 ± 5.2 | 86.9 ± 4.9 | 0.3 |
| (range) | (78–93) | (79–94) | (76–95) | (76–95) | |
| No. (%) Males | 3 (25) | 4 (44) | 2 (25) | 9 (30) | 0.4* |
| Years of education | |||||
| Mean ± SD | 17.3 ± 4.2 | 16.9 ± 3.4 | 18.9 ± 3.4 | 17.8 ± 3.7 | 0.4 |
| (range) | (10–25) | (10–20) | (14–26) | (10–26) | |
| Postmortem interval (hours) | |||||
| Mean ± SD | 4.8 ± 2.0 | 5.2 ± 2.0 | 4.5 ± 1.9 | 4.8 ± 1.9 | 0.7 |
| (range) | (1.0–8.1) | (2.0–8.6) | (1.5–8.1) | (1.0–8.6) | |
| No. (%) with ApoE±4 allele | 0 (0) | 3 (33) | 6 (50) | 9 (27) | 0.02* |
| MMSE | |||||
| Mean ± SD | 28.3 ± 1.7 | 27.4 ± 2.4 | 18.7 ± 8.7 | 24.4 ± 6.8 | 0.0001† |
| (range) | (26–30) | (23–30) | (2–28) | (2–30) | |
| Global cognitive score | |||||
| Mean ± SD | −0.1 ± 0.2 | −0.5 ± 0.3 | −1.7 ± 0.8 | −0.8 ± 0.9 | 0.0001† |
| (range) | (−0.4, 0.3) | (−0.9, 0.0) | (−3.7, −0.9) | (−3.7, 0.3) | |
| Braak scores | |||||
| I–II | 4 | 1 | 1 | 6 | |
| III–IV | 7 | 6 | 5 | 18 | 0.08 |
| V–VI | 1 | 2 | 6 | 9 | |
| NIA Reagan diagnosis (likelihood of AD) | |||||
| No AD | 0 | 0 | 0 | 0 | |
| Low | 8 | 4 | 1 | 13 | 0.006‡ |
| Intermediate | 4 | 3 | 7 | 14 | |
| High | 0 | 2 | 4 | 6 | |
| CERAD diagnosis (likelihood of AD) | |||||
| No AD | 3 | 3 | 0 | 6 | |
| Low | 3 | 1 | 0 | 4 | 0.05‡ |
| Intermediate | 6 | 3 | 8 | 17 | |
| High | 0 | 2 | 4 | 6 | |
AD, Alzheimer disease; MCI, mild cognitive impairment; MMSE, mini-mental status exam; NCI, no cognitive impairment; SD, standard deviation.
*
Chi-square test.
†
Pairwise comparisons with Tukey’s correction showed no difference between NCI and MCI, but both were significantly different from AD.
‡
Pairwise comparisons with Tukey’s correction showed a significant difference between NCI and AD only.