TABLE 3.
Summary of Quantification of p75NTR +, p75NTR +/TOC1+, and TOC1+ Neurons
| Clinical Diagnosis |
Comparison by Diagnosis Group (p Value) | |||
|---|---|---|---|---|
| NCI | MCI | AD | ||
| (n = 12) | (n = 9) | (n = 12) | ||
| p75NTR+ (×103) | ||||
| Mean ± SD | 205.8 ± 47.6 | 202.1 ± 44.0 | 156.6 ± 57.4 | 0.046* |
| (range) | (136.8–297.9) | (148.6–277.0) | (92.6–252.0) | |
| p75NTR+/TOC1+ (×103) | ||||
| Mean ± SD | 0.9 ± 0.9 | 1.9 ± 2.5 | 6.0 ± 8.7 | 0.07 |
| (range) | (0–2.4) | (0–8.4) | (0.1–31.4) | |
| TOC1+ (×103) | ||||
| Mean ± SD | 0.7 ± 0.9 | 0.5 ± 0.5 | 2.3 ± 3.4 | 0.098 |
| (range) | (0–2.4) | (0–1.3) | (0.07–9.6) | |
AD, Alzheimer disease; MCI, mild cognitive impairment; NCI, no cognitive impairment; p75NTR, low-affinity neurotrophin receptor; SD, standard deviation; TOC1, tau oligomer complex 1.
*
Post-hoc comparison with Tukey’s correction showed a significant difference between NCI and AD only.