Table 2.

Nonsynonymous variants identified through targeted sequencing of the LAMB4 gene. LAMB4 was sequenced from genomic DNA isolated from 148 patients with sporadic diverticulitis and the five members of the proband family. Not including the variant identified in the proband family, seven variants with scaled CADD scores above 10 were identified in 52 of the samples. All the variants were confirmed by Sanger sequencing. Variant in the proband family is number 4 on the list.

	Chr.	Position	Reference Nucleotide	Alternate Nucleotide	Reference Amino Acid	Alternate Amino Acid	Residue Number	Scaled CADD	RS Number	ExAC Freq.	Our Data Set Freq.	Our data set
1	7	107746432	G	A	H	Y	234	25.8	rs2074749	0.029	0.026	4
2	7	107706895	T	C	N	S	866	25.1	rs2240445	0.028	0.0128	2
3	7	107696101	A	C	V	G	1244	24.8	rs147992634	0.005	0.00641	1
4	7	107738905	C	T	D	N	435	23.9			0.0192	3
5	7	107746309	G	A	R	C	275	23.4		0.0004	0.00641	1
6	7	107749668	C	G	R	T	117	17.75	rs149874137	0.015	0.0128	2
7	7	107720162	C	A	V	F	591	15.13	rs9690688	0.095	0.128	20
8	7	107720090	G	T	P	T	615	13.76		0.0003	0.00641	1
9	7	107677984	G	A	H	Y	1510	8.412	rs1627354	0.097	0.115	18