Table 4.

Longitudinal associations of serum and urine albumin concentrations with incident reduced eGFR

Outcome = incident CKD (556/1986=28%)
	n	No. of patients incident CKD	Unadjusted	Model 1a	Model 2b	Model 3c
			IRR (95% CI)	IRR (95% CI)	IRR (95% CI)	IRR (95% CI)
Serum albumin			IRR (95% CI)	IRR (95% CI)	IRR (95% CI)	IRR (95% CI)
per SD decrease = 0.31	1986	556	1.09 (0.84–0.98)**	1.12 (1.06–1.19)*	1.12 (1.05–1.18)**	1.13 (1.06–1.19)**
Quartiles
>4.21	379	105	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
4.0–4.20	434	123	1.04 (0.83–1.30)	1.13 (0.91–1.40)	1.04 (0.82–1.31)	1.03 (0.81–1.31)
3.81–4.00	509	127	0.94 (0.75–1.17)	0.99 (0.79–1.24)	0.94 (0.74–1.19)	0.98 (0.77–1.26)
≤3.80	664	201	1.18 (0.96–1.45)	1.32 (1.07–1.62)**	1.26 (1.01– 1.56)**	1.29 (1.03–1.62)**
Urine ACR
Urine ACR (per doubling)			1.09 (1.05–1.14)*	1.08 (1.04–1.13)*	1.07 (1.03–1.12)*	1.08 (1.04–1.13)*
Urine ACR (>30 mg/g)	271	108	1.79 (1.51– 2.13)*	1.49 (1.25–1.77)*	1.51 (1.25–1.81)*	1.56 (1.30–1 .88)*
Quartiles
≤4.00	554	135	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
4.01–7.89	533	138	1.09 (0.89–1.35)	1.04 (0.85–1.27)	0.91 (0.73–1.13)	0.94 (0.76–1.17)
7.90–20.20	496	136	1.18 (0.96–1.46)	1.04 (0.85–1.28)	0.95 (0.77–1.17)	0.99 (0.80–1.22)
>20.20	381	143	1.84 (1.50–2.25)*	1.48 (1.21–1.82)*	1.38 (1.11–1.71)*	1.44 (1.16–1.79)*

^aModel 1: demographics and risk factors; model adjusted for age, gender, race, site, DM, SBP, HTN meds, smoking, prevalent cardiovascular disease, high-density lipoprotein, low-density lipoprotein and eGFR.

^bModel 2: inflammation and health; model further adjusted for CRP, IL-6, TNF-α and self-reported health status.

^cModel 3: further adjusted for urine albumin (or serum albumin).

^*P < 0.001.

^**P < 0.05.

CI, confidence interval; IRR, incidence rate ratio.