Figure 1.

Circulating androgens improve muscle mass and survival in Dystrophin/utrophin double mutant mice. Dystrophin/utrophin (dmd/utrn) double mutant mice (n = 6 in sham-operated and 8 in castrated group; 4 weeks old) were sham-operated or castrated and weekly body weight (A, left panel) and lean mass (A, right panel) by MRI were measured and their survival monitored (B). (C) Serum testosterone levels were measured in sham-operated or castrated mdx mice aged 4, 8 and 12 weeks (n = 4/time point) using ELISA. Values are represented as average ± SE. *Significance at P < 0.01.