Figure 4.
(a) PET images of Au vesicles radiolabeled with 64Cu radiotracers at different time points. Yellow arrows indicate tumors. (b) Cancer therapy study in a subcutaneous mouse tumor model. X-ray irradiation (8 Gy) was applied 24 h after i.v. injection of different formulations, and mouse tumor volume and survival rate were recorded until 20 and 50 days post-irradiation, respectively (n = 5, ***p < 0.001). The numbers indicate the quantitative percentage (%) of tumor volume inhibition values for each group. (c) Representative H&E staining (left) and TEM images (right) show changes in morphologies and microstructures of tumors after different treatments. Scale bar: 20 μm (black, left) and 5 μm (white, right). Yellow arrows indicate distortion and shrinkage of nuclei or chromatin migration in H&E images, and nuclear condensation, chromatin fragmentation, or formation of apoptotic bodies in TEM images.