Figure 2:

Evaluation of MLL binding to 3FY/4FF KIX A) Solution structure (PDB ID: 2AGH) showing the native MLL peptide (gold) near Y631 (red) and F612 (blue). B) PrOF NMR results from MLL binding demonstrating slow chemical exchange binding kinetics. The concentration of 3FY/4FF KIX in the samples was 51 μM. Slashes in the baseline denote edited spectra to focus on the fluorine resonances. Full spectra are shown in Figure S3. * denotes an impurity that others have identified to be fluoride.^[12]